Effects of chronic ingestion of sodium fluoride on myocardium in a second generation of rats
Identifieur interne : 001E78 ( Main/Exploration ); précédent : 001E77; suivant : 001E79Effects of chronic ingestion of sodium fluoride on myocardium in a second generation of rats
Auteurs : Ekrem Cicek [Turquie] ; Gulsen Aydin [Turquie] ; Mehmet Akdogan [Turquie] ; Huseyin Okutan [Turquie]Source :
- Human and Experimental Toxicology [ 0960-3271 ] ; 2005-02.
English descriptors
- Teeft :
- Albino rats, Antioxidant enzymes, Ascorbic acid, Beneficial effects, Biochemical changes, Blood samples, Cardiac muscle, Cardiovascular surgery, Chinoy, Chronic effects, Chronic fluorosis, Cicek, Clumped fibers, Control group, Cytoplasmic, Cytoplasmic vacuolation, Cytoplasmic vacuolisation, Demirel, Different doses, Drinking water, Environ toxicol, Exact nature, Experimental fluorosis, Experimental groups, Experimental parameters, Experimental study, Extensive cytoplasmic vacuole formation, First generation, Fluoridated water, Fluoride, Fluoride toxicity, Fluorine symposium, Fluorosis, Free radicals, Gestation period, Glutathione, Glutathione peroxidase catalase, Hayat danone spring water, High doses, Histopathological, Histopathological changes, Insignificant increase, Laboratory animals, Lactation period, Lipid, Lipid peroxidation, Male rats, Medical school, Multigenerational administration, Myocardial, Myocardial cell necrosis, Myocardial changes, Myocardial damage, Myocardial tissue, Myocardial tissue morphology, Myocardial tissues, Nucleus dissolution, Other hand, Oxidative damage, Oxidative stress, Peroxidation, Pregnant rats, Present study, Pulmonary damage, Radical reactions, Rat, Reactive oxygen species, Reproductive functions, Second generation, Second generation adult, Shashi, Significant differences, Significant increase, Sodium fluoride, Stock solution, Suckling period, Suleyman demirel university, Superoxide, Superoxide dismutase, Superoxide radicals, Survival rates, Tbars, Tbars level, Tbars levels, Thick arrows, Thiobarbituric substance, Tissue samples, Toxic effects, Toxicity, Treatment groups, Wistar strain.
Abstract
Possible effects of long term exposure (6 months) to sodium fluoride (NaF) through drinking water on the morphology and biochemistry of myocardial tissue in second generation adult male rats were investigated. Wistar strain female and male rats were reared until the second generation of rats obtained, during which they were given 1, 10, 50 and 100 mg/L NaF in drinking water. Of the second generation, 28 male rats were divided into four groups and had the same treatment. All the second generation rats were sacrificed and autopsied at the end of the 6 months. In the samples of myocardial tissues, the levels of serum fluoride and the activities of principal antioxidant enzymes were determined, and a histopathological examination was conducted. Significant histopathological changes were found in the myocardial tissue of rats treated with 50 and 100 mg/L NaF. These were myocardial cell necrosis, extensive cytoplasmic vacuole formation, nucleus dissolution in myosits, swollen and clumped myocardial fibers, fibrillolysis, interstitial oedema, small hemorrhagic areas and hyperaemic vessels. Additionally, the increased activities of superoxide dismutase (SOD), glutathione peroxidase (GSH–Px), catalase (CAT) and thiobarbituric acid–reactive substance (TBARS) levels were observed in the myocardial tissues of rats treated with 10 and 50 mg/L NaF. On the other hand, the activities of SOD, GSH–Px, and CAT decreased, but the TBARS levels increased in the myocardial tissues of rats treated with 100 mg/L. The present results revealed that prolonged ingestion of fluoride through drinking water, particularly with high doses, induced significant histopathological and biochemical changes leading to myocardial tissue damage.
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DOI: 10.1191/0960327105ht505oa
Affiliations:
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Oztunc A., No. 1 D: 4 32050, Isparta</wicri:regionArea><wicri:noRegion>Isparta</wicri:noRegion></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Human and Experimental Toxicology</title><idno type="ISSN">0960-3271</idno><idno type="eISSN">1477-0903</idno><imprint><publisher>Sage Publications</publisher><pubPlace>Sage CA: Thousand Oaks, CA</pubPlace><date type="published" when="2005-02">2005-02</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="79">79</biblScope><biblScope unit="page" to="87">87</biblScope></imprint><idno type="ISSN">0960-3271</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0960-3271</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Albino rats</term><term>Antioxidant enzymes</term><term>Ascorbic acid</term><term>Beneficial effects</term><term>Biochemical changes</term><term>Blood samples</term><term>Cardiac muscle</term><term>Cardiovascular surgery</term><term>Chinoy</term><term>Chronic effects</term><term>Chronic fluorosis</term><term>Cicek</term><term>Clumped fibers</term><term>Control group</term><term>Cytoplasmic</term><term>Cytoplasmic vacuolation</term><term>Cytoplasmic vacuolisation</term><term>Demirel</term><term>Different doses</term><term>Drinking water</term><term>Environ toxicol</term><term>Exact nature</term><term>Experimental fluorosis</term><term>Experimental groups</term><term>Experimental parameters</term><term>Experimental study</term><term>Extensive cytoplasmic vacuole formation</term><term>First generation</term><term>Fluoridated water</term><term>Fluoride</term><term>Fluoride toxicity</term><term>Fluorine symposium</term><term>Fluorosis</term><term>Free radicals</term><term>Gestation period</term><term>Glutathione</term><term>Glutathione peroxidase catalase</term><term>Hayat danone spring water</term><term>High doses</term><term>Histopathological</term><term>Histopathological changes</term><term>Insignificant increase</term><term>Laboratory animals</term><term>Lactation period</term><term>Lipid</term><term>Lipid peroxidation</term><term>Male rats</term><term>Medical school</term><term>Multigenerational administration</term><term>Myocardial</term><term>Myocardial cell necrosis</term><term>Myocardial changes</term><term>Myocardial damage</term><term>Myocardial tissue</term><term>Myocardial tissue morphology</term><term>Myocardial tissues</term><term>Nucleus dissolution</term><term>Other hand</term><term>Oxidative damage</term><term>Oxidative stress</term><term>Peroxidation</term><term>Pregnant rats</term><term>Present study</term><term>Pulmonary damage</term><term>Radical reactions</term><term>Rat</term><term>Reactive oxygen species</term><term>Reproductive functions</term><term>Second generation</term><term>Second generation adult</term><term>Shashi</term><term>Significant differences</term><term>Significant increase</term><term>Sodium fluoride</term><term>Stock solution</term><term>Suckling period</term><term>Suleyman demirel university</term><term>Superoxide</term><term>Superoxide dismutase</term><term>Superoxide radicals</term><term>Survival rates</term><term>Tbars</term><term>Tbars level</term><term>Tbars levels</term><term>Thick arrows</term><term>Thiobarbituric substance</term><term>Tissue samples</term><term>Toxic effects</term><term>Toxicity</term><term>Treatment groups</term><term>Wistar strain</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Possible effects of long term exposure (6 months) to sodium fluoride (NaF) through drinking water on the morphology and biochemistry of myocardial tissue in second generation adult male rats were investigated. Wistar strain female and male rats were reared until the second generation of rats obtained, during which they were given 1, 10, 50 and 100 mg/L NaF in drinking water. Of the second generation, 28 male rats were divided into four groups and had the same treatment. All the second generation rats were sacrificed and autopsied at the end of the 6 months. In the samples of myocardial tissues, the levels of serum fluoride and the activities of principal antioxidant enzymes were determined, and a histopathological examination was conducted. Significant histopathological changes were found in the myocardial tissue of rats treated with 50 and 100 mg/L NaF. These were myocardial cell necrosis, extensive cytoplasmic vacuole formation, nucleus dissolution in myosits, swollen and clumped myocardial fibers, fibrillolysis, interstitial oedema, small hemorrhagic areas and hyperaemic vessels. Additionally, the increased activities of superoxide dismutase (SOD), glutathione peroxidase (GSH–Px), catalase (CAT) and thiobarbituric acid–reactive substance (TBARS) levels were observed in the myocardial tissues of rats treated with 10 and 50 mg/L NaF. On the other hand, the activities of SOD, GSH–Px, and CAT decreased, but the TBARS levels increased in the myocardial tissues of rats treated with 100 mg/L. The present results revealed that prolonged ingestion of fluoride through drinking water, particularly with high doses, induced significant histopathological and biochemical changes leading to myocardial tissue damage.</div></front></TEI><affiliations><list><country><li>Turquie</li></country></list><tree><country name="Turquie"><noRegion><name sortKey="Cicek, Ekrem" sort="Cicek, Ekrem" uniqKey="Cicek E" first="Ekrem" last="Cicek">Ekrem Cicek</name></noRegion><name sortKey="Akdogan, Mehmet" sort="Akdogan, Mehmet" uniqKey="Akdogan M" first="Mehmet" last="Akdogan">Mehmet Akdogan</name><name sortKey="Aydin, Gulsen" sort="Aydin, Gulsen" uniqKey="Aydin G" first="Gulsen" last="Aydin">Gulsen Aydin</name><name sortKey="Okutan, Huseyin" sort="Okutan, Huseyin" uniqKey="Okutan H" first="Huseyin" last="Okutan">Huseyin Okutan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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